• Urolithin A CAS 1143-70-0
Urolithin A CAS 1143-70-0
  • HHDPHARM
  • Wuhan,China

1. Wuhan hengheda pharm offer Urolithin A, Urolithin B, Urolithin C series products
2. Custom synthesis novel compounds

Urolithin A CAS 1143-70-0

Product name

Urolithin A

Other name

6H-Dibenzo[b,d]pyran-6-one,3,8-dihydroxy-; 2',7-Dihydroxy-3,4-benzocoumarin; 2-Biphenylcarboxylicacid, 2',4,4'-trihydr

CAS

1143-70-0

Purity

Min 98%

MF:

C13H8O4

MW:

228.2

Structure

Urolithin A

Usage

antioxidant; anti-inflammatory; anticancer


Description:

Urolithins are microflora human metabolites of dietary ellagic acid derivatives such as ellagitannins. They are produced in the human gut, and found in the urine in the form of urolithin B glucuronide after absorption of ellagitannins-containing food such as pomegranate,strawberries, red raspberries, walnuts or oak-aged red wine.
During intestinal metabolism by bacteria, ellagitannins and punicalagins are converted to urolithins, which have unknown biological activity in vivo in humans. Urolithins metabolites of pomegranate juice ellagitannins localize specifically in the prostate gland, colon, and intestinal tissues of mice.
Ellagitannins exhibit low bioavailability and are transformed in the gut to ellagic acid and its microbiota metabolites. Urolithins are found in plasma mostly as glucuronides at low concentrations.
Urolithins production is dependent on the gut microbiome enterotype. Individuals producing urolithins show a much higher abundance of the Clostridium leptum group of Firmicutes phylum than Bacteroides or Prevotella.
Urolithin M7 has also been synthetized from 2-hydroxy-4-methoxybenzaldehyde using the inverse electron-demand Diels–Alder reaction.

In laboratory studies, urolithin A was shown to induce mitophagy, which is a selective recycling of mitochondria by autophagy, a process that cleans defective mitochondria following damage or stress, and tends to become less efficient during aging. This effect has been observed in different animal species (mammalian cells, rodents and C. elegans).


FAQ
Do we have the test reports for our products provided by the independent third party?
Every batch of our product was tested by authorized independent third party, Analysis testing center, Shanghai branch, Chinese Academy of Science. We send goods to customers with test report and COA. Our products were also tested by American Analytical Chemistry Laboratories and Chromadex too....more
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