Guaiazulene, also azulon or 1,4-dimethyl-7-isopropylazulene, is a dark blue crystalline hydrocarbon. A derivative of azulene, guaiazulene is a bicyclic sesquiterpene that is a constituent of some essential oils, mainly oil of guaiac and chamomile oil, which also serve as its commercial sources. Various soft corals also contain guaiazulene as a principal pigment. Its low melting point makes guaiazulene difficult to handle, in contrast to the crystalline nature of the parent azulene. The electronic structure (and colors) of guaiazulene and azulene are very similar.

1) Anti-inflammatory, immunologic and antiallergenic effects. It inhibits the degranulation of mast cells.
2) It can strengthen fortified factors,has good function on low acid or free acid ulceration.
3) Reduce the amount of pepsin.

1) Applied in daily chemical field, especially in dental cream for oral protection.
2) Applied in pharmaceutical field for gastric ulcer treatment.