WAY 262611 dihydrochloride | DKK1 inhibitor | WAY262611 CAS 2108968-58-5
- Wuhan Hengheda Pharm Co.,Ltd
- China
- Immediately after payment
- 500/g batch
Direct manufacture
Bulk quantity
Min 98%
Free samples
Product Name | WAY262611 Dihydrochloride |
Brand | HHDPHARM |
CAS No. | 2108968-58-5 |
| Appearance | White powders |
Storage | Room temperaure |
MF | C20H22N4.2HCl |
Shelf Life | 2 yeaars |
Purity | 99% |
| Solubility | Soluble in water and DMSO |
| Grade | Enterprise Standard |
Inhibitor of Dickkopf-1 (DKK1); WAY 262611 is a wingless Wnt/β-Catenin signaling agonist with an inhibitory effect on DKK1, displaying an EC50 value of 0.63 μM for DKK1-mediated TCF-Luciferase, no affinity for GSK-3β (IC50 value >100 μM) and enhancing the bone formation rate in ovariectomized (OVX) rats following oral adminstration. Dickkopf-1 (DKK1) is a soluble inhibitor of Wnt-3a mediated Wnt/β-catenin signaling required for embryonic head development. It regulates Wnt signaling by binding to the Wnt coreceptor lipoprotein-related protein-5 (LRP5)/Arrow, and Kremen2 (Kr2) simultaneously.
