Nutrition Supplement

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    Wuhan HHD RU58841 CAS 154992-24-2 Hair Regrowth

    Wuhan HHD RU58841 CAS 154992-24-2 Hair Regrowth

    RU58841 (also known as RU-58841, PSK-3841 or HMR-3841) is a compound that has been garnering attention for RU58841 phenomenal response to hair growth. Anti-androgens have potential to be used to treat some 'male' cancers such as prostate cancer, as well as possibly targeting skin conditions including acne and male-pattern baldness. RU58841 differs from other anti-androgens in that rather than trying to reduce or block the production of testosterone or DHT, it focuses on the testosterone receptor.

    RU58841 is a specific androgen receptor antagonist or a so called anti-androgen. This non steroidal topical androgen antagonist was investigated for therapeutic value in androgenetic alopecia and acne.

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    Wuhan HHD MACET N-Acetyl-L-Cysteine Ethyl Ester(NACET) CAS 59587-09-6

    Wuhan HHD MACET N-Acetyl-L-Cysteine Ethyl Ester(NACET) CAS 59587-09-6

    Recent large clinical trials failed to confirm the supposed beneficial effects of N-acetylcysteine (NAC) in preventing oxidative stress-related diseases. This may be due to its low bioavailability. We thought that esterification of the carboxyl group of NAC to produce N-acetylcysteine ethyl ester (NACET) would drastically increase the lipophilicity of NAC, thus greatly improving its pharmacokinetics. In the present work, we report on representative chemical, pharmacological and anti-oxidant properties of NACET, especially in direct comparison with its congener NAC. We found that NACET is rapidly absorbed in rats after oral administration but reaches very low concentrations in plasma. This is due to a unique feature of NACET: it rapidly enters the cells where it is trapped being transformed into NAC and cysteine. After oral treatment, NACET (but not NAC) was able to increase significantly the glutathione content of most tissues examined, brain included, and to protect from paracetamol intoxication in the rat. NACET has also the unique feature to accumulate in human erythrocytes where it behaves as a potent protector against hydroperoxide-induced oxidative damage. Our study shows that being able to enter cells and to produce NAC and cysteine, NACET increases circulating hydrogen sulfide (H(2)S), thus representing a good candidate for the oral use as an H(2)S producer, with clear advantages over NAC. NACET has the potential to substitute NAC as a mucolytic agent, as a paracetamol antidote and as a GSH-related antioxidant.

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    Wuhan HHD L-5-Methyltetrahydrofolate CAS 151533-22-1

    Wuhan HHD L-5-Methyltetrahydrofolate CAS 151533-22-1

    Hot Selling Levomefolic Acid, L-5-MTHF, Levomefolate Calcium,L-5-Methyltetrahydrofolate, L-Methylfolate Calcium Powder
    L-methylfolate is the biologically active form of vitamin B9. That means it is the form the human body can actually use in circulation.
    It goes by several other common names including:
    L-Methylfolate calcium Cas 15133-22-1
    Levomefolic acid Cas 31690-09-2;
    5-methyltetrahydrofolate Cas 26560-38-3 is the primary biologically active form of folate used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine. It is also the form found in circulation and transported across membranes into tissues and across the blood-brain barrier. In the cell, L-methylfolate is used in the methylation of homocysteine to form methionine and tetrahydrofolate (THF). THF is the immediate acceptor of one carbon units for the synthesis of thymidine-DNA, purines (RNA and DNA) and methionine. The un-methylated form, folic acid (vitamin B9), is a synthetic form of folate, and must undergo enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR) to become biologically active.
    It is synthesized in the absorptive cells of the small intestine from polyglutamylated dietary folate. It is a methylated derivative of tetrahydrofolate. Levomefolic acid is generated by MTHFR from 5,10-methylenetetrahydrofolate (MTHF) and used to recycle homocysteine back to methionine by methionine synthase (MS).
    L-methylfolate is water-soluble and primarily excreted via the kidneys. In a study of 21 subjects with coronary artery disease, peak plasma levels were reached in one to three hours following oral or parenteral administration. Peak concentrations were found to be more than seven times higher than folic acid

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  • Wuhan HHD Setipiprant CAS 866460-33-5 Hair Loss Treatment

    Wuhan HHD Setipiprant CAS 866460-33-5 Hair Loss Treatment

    Setipiprant (INN) (developmental code names ACT-129,968, KYTH-105) is a drug originally developed by Actelionwhich acts as a selective, orally available antagonist of the prostaglandin D2 receptor 2 (DP2). Setipiprant was initially researched as a treatment for allergies and inflammatory disorders, particularly asthma, but despite being well tolerated in clinical trials and showing reasonable efficacy against allergen-induced airway responses in asthmatic patients,Setipiprant failed to show sufficient advantages over existing drugs and was discontinued from further development in this application.

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  • Wuhan HHD Magnesium L-Threonate CAS 778571-57-6

    Wuhan HHD Magnesium L-Threonate CAS 778571-57-6

    Magnesium is an essential dietary mineral, and is the second most common electrolyte in the body. Magnesium deficiencies are common in the western diet, and magnesium deficiencies have been linked to a number of adverse health effects including weakness, cramps, anxiety, and high blood pressure.

    There are many supplemental forms of Magnesium, but what makes Magnesium L-Threonate unique is that research has shown that this form in particular can improve brain magnesium and may have cognitive enhancing properties. Research on Magnesium L-Threonate has shown it to provide improvements on learning and recall, as well as slowing age-related cognitive decline.

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