O-304 is a novel small-molecule activator of AMP-activated protein kinase (AMPK) with demonstrated potential in diabetes, obesity, and aging-related disease research. As a dual-acting compound, O-304 enhances cellular energy homeostasis by modulating glucose uptake and lipid metabolism, making it a critical tool for preclinical studies targeting metabolic disorders.

Key Features

• High Bioavailability: Optimized pharmacokinetics (oral bioavailability >80%) for in vivo efficacy studies.

• Selective AMPK Activation: Targets β1 subunit with EC50 of 0.3 μM (HEK293 cells), minimal off-target effects.

• Reproducible Results: Batch-to-batch consistency (HPLC purity ≥98%) ensured by cGMP-compliant synthesis.

• Broad Applications: Validated in diabetic models (db/db mice), atherosclerosis, and NAFLD research.

Applications

1. 1.

   Diabetes & Obesity Research

• Enhances glucose uptake in skeletal muscle (in vivo/in vitro models).

• Reduces hepatic gluconeogenesis and adipogenesis.

2. 2.

   Aging & Longevity Studies

• Mimics caloric restriction effects via AMPK-mTOR pathway modulation.

3. 3.

   Cardiometabolic Disease

• Improves vascular function in atherosclerosis models.