- HHD
- Wuhan Hubei
- In Stock
- In Stock
1. Min 98%
2. Bulk in stock
3. Good price
4. Analysis report offer
Product Name | ISRIB |
Other Name | N,N'-(Cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide) |
CAS No. | 548470-11-7 |
Appearance | White powder |
Purity | 98% |
MF | C22H24Cl2N2O4 |
Solubility | DMSO |
Storage | Room temperature |
Shelf Life | 2 years |
Grade | Food Grade |
Product Name | trans-ISRIB（trans isomer) |
Other Name | 2-(4-chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide |
CAS No. | 1597403-47-8 |
Appearance | White powder |
Purity | 98% |
MF | C22H24Cl2N2O4 |
Solubility | DMF: 2 mg/ml DMSO: 2 mg/ml |
Storage | Room temperature |
Shelf Life | 2 years |
Grade | Food Grade |
First reported, potent and selective inhibitor of the ‘integrated stress response’ (ISR) and a potent inhibitor of PERK signaling. ISRIB potently reverses the effects of eIF2α phosphorylation (IC50 value of 5 nM for inhibition of ATF4-luciferase reporter). Trans-ISRIB reduces the viability of cells subjected to PERK-activation by chronic endoplasmic reticulum stress, and proved to be 100-fold more potent than cis-ISRIB, indicating that the compound’s interaction with its cellular target is stereospecific.
1. Trans ISRIB powder has vasodilating, blood thinning, and memory-enhancing actions.
2. Trans ISRIB powder acts as a cerebral stimulant and vasodilator.
3. Trans ISRIB powder is used to treat arteriosclerosis.
4. Trans ISRIB powder is very effective in curing dementia caused due to insufficient blood supply to the brain.
5. Trans ISRIB powder interferes with cells' ability to synthesize DNA and RNA.
Every batch of our product was tested by authorized independent third party, Analysis testing center, Shanghai branch, Chinese Academy of Science. We send goods to customers with test report and COA. Our products were also tested by American Analytical Chemistry Laboratories and Chromadex too....more
