N-Acetyl-D-mannosamine CAS 7772-94-3

Common Name	N-Acetylmannosamine
Description	N-Acetylmannosamine is a monosaccharide that is used as a precursor in the chemical or enzymatic synthesis of the neuraminic acids found in glycolipids and glycoproteins. N-Acetyl-D-mannosamine (ManNAc) is a specific substrate for the synthesis of N-acetylneuraminic acid, the essential precursor of bacterial capsular polysialic acid (PA). N-Acetyl-D-mannosamine is used for the synthesis of sialic acid. It is also a synthetic intermediate for a number of carbohydrate-derived families of biologically active compounds and pharmaceutical candidates. N-Acetylmannosamine is a microbial metabolite of Escherichia (PMID: 7772033 ).
Structure	MOLSDF3D-SDFPDBSMILESInChI View 3D Structure
Synonyms	Value Source beta-ManNAc ChEBI N-Acetyl-beta-mannosamine ChEBI b-ManNAc Generator Β-mannac Generator N-Acetyl-b-mannosamine Generator N-Acetyl-β-mannosamine Generator 2-Acetamido-2-deoxy-D-mannopyranose HMDB 2-Acetamido-2-deoxy-D-mannose HMDB ManNAc HMDB N-Acetyl-D-mannosamine HMDB N-Acetylmannosamine, (D)-isomer HMDB N-Acetylmannosamine, (L)-isomer HMDB

N-Acetyl-D-mannosamine (ManNAc) is a specific substrate for the synthesis of N-acetylneuraminic acid, the essential precursor of bacterial capsular polysialic acid (PA). N-Acetyl-D-mannosamine is used for the synthesis of sialic acid. It is also a synthetic intermediate for a number of carbohydrate-derived families of biologically active compounds and pharmaceutical candidates. It is studied for its effect on capsular polysialic acid production.

N-Acetyl-D-mannosamine (ManNAc) is an essential precursor of N-acetylneuraminic acid (NeuAc), the specific monomer of polysialic acid. Transport studies in the E. coli K1 strain have been performed to probe the effect of ManNAc on capsular polysialic acid production.

N-Acetyl-D-mannosamine (ManNAc) is used as a substrate to identify, differentiate and characterize enzymes such as N-acetyl-glucosamine epimerase(s) and aldolase(s). N-Acetyl-D-mannosamine is used for the synthesis of of N-acetylneuraminic acid.

N-acetyl-D-mannosamine is an N-acetylmannosamine having D-configuration. It has a role as a bacterial metabolite. It is a N-acyl-D-mannosamine, a N-acetyl-D-hexosamine and a N-acetylmannosamine.