• L-5-Methyltetrahydrofolate CAS 151533-22-1
  • L-5-Methyltetrahydrofolate CAS 151533-22-1
L-5-Methyltetrahydrofolate CAS 151533-22-1
  • Wuhan Hengheda Pharm Co.,Ltd
  • China
  • Immediately after payment
  • 1000kg/month

Hot Selling Levomefolic Acid, L-5-MTHF, Levomefolate Calcium,L-5-Methyltetrahydrofolate, L-Methylfolate Calcium Powder
L-methylfolate is the biologically active form of vitamin B9. That means it is the form the human body can actually use in circulation.
It goes by several other common names including:
L-Methylfolate calcium Cas 15133-22-1
Levomefolic acid Cas 31690-09-2;
5-methyltetrahydrofolate Cas 26560-38-3 is the primary biologically active form of folate used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine. It is also the form found in circulation and transported across membranes into tissues and across the blood-brain barrier. In the cell, L-methylfolate is used in the methylation of homocysteine to form methionine and tetrahydrofolate (THF). THF is the immediate acceptor of one carbon units for the synthesis of thymidine-DNA, purines (RNA and DNA) and methionine. The un-methylated form, folic acid (vitamin B9), is a synthetic form of folate, and must undergo enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR) to become biologically active.
It is synthesized in the absorptive cells of the small intestine from polyglutamylated dietary folate. It is a methylated derivative of tetrahydrofolate. Levomefolic acid is generated by MTHFR from 5,10-methylenetetrahydrofolate (MTHF) and used to recycle homocysteine back to methionine by methionine synthase (MS).
L-methylfolate is water-soluble and primarily excreted via the kidneys. In a study of 21 subjects with coronary artery disease, peak plasma levels were reached in one to three hours following oral or parenteral administration. Peak concentrations were found to be more than seven times higher than folic acid

L-5-Methyltetrahydrofolate CAS 151533-22-1

L-5-Methyltetrahydrofolate calcium

Product name:  L-5-Methyltetrahydrofolate calcium

Specification: 99%

CAS No.: 151533-22-1

Appearance: Off-white to light-yellow powder

Molecular Formula: C20H23CaN7O6

Molecular Weight: 497.5179 


In concert with vitamin B12, 5-MTHF functions as a methyl-group donor involved in the conversion of the amino acid homocysteine to methionine. Methyl-group donation is vital to many biochemical conversion processes, including the synthesis of serotonin, melatonin, and DNA.

It is important for women of childbearing age to get enough folic acid - not just those who are planning to become pregnant. Only 50 percent of pregnancies are planned, so any woman who could become pregnant should get enough folic acid every day - especially before conception and during early pregnancy.

It is an intermediate product of the metabolism of Folic Acid; the active form into which that acid is converted in the body, ascorbic acid being a necessary factor in the conversion process.

 L-5-Methyltetrahydrofolate Calcium(Levomefolate calcium), a naturally occurring form of halogenated methyl derivatives of folic acid, is the most biologically active and functional form of folic acid and is more easily absorbed than normal folic acid.Lack of folic acid is usually caused by a lack of vitamin deficiency leads to absorb, during pregnancy and lactation, children need more folic acid during the period of growth, the absorption or metabolic changes, or under the influence of drugs, to eat food rich in folic acid can't guarantee dose, so need to supplement.




About 10 years ago, Europe has use L-5-Methyltetrahydrofolate Calcium in drug, 
it has affecting the treatment of pregnant care, homocysteine control, depression, 
ementia and cardiovascular disease.



1. Mainly for folic acid antagonists (such as methotrexate, pyrimethamine, benzyl cefalexin and trimethoprim) antidote, it's usually used for prevention of methotrexate dose or overdose treatment caused severe toxic effects.
2. Folic acid treatment of the following diseases, such as inflammatory diarrhea and protein-energy malnutrition (poor nutrition), pregnancy or infancy megaloblastic anemia caused by poor.
3. as adjuvant therapy for colon cancer, rectal cancer.
4. Combined with 5-FU and treatment of digestive tract tumors or other 5-FU-sensitive tumors. High-dose CF used in conjunction with 5-FU (LF), the basic programme is currently the treatment of colon and rectal cancer.
5. For children with leukemia, lymphoma, and osteosarcoma, such as high dose MTX treatment when rescued. 

Do we have the test reports for our products provided by the independent third party?
Every batch of our product was tested by authorized independent third party, Analysis testing center, Shanghai branch, Chinese Academy of Science. We send goods to customers with test report and COA. Our products were also tested by American Analytical Chemistry Laboratories and Chromadex too....more
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