• N-Methyl Tyramine Hydrochloride CAS 370-98-9

    Pre Workout Supplement N-Methyl Tyramine hydrochloride, N-Methyltyramine HCL N-Methyltyramine (NMT), also known as 4-hydroxy-N-methylphenethylamine, is a human trace amine and natural phenethylamine alkaloid found in a variety of plants. As the name implies, it is the N-methyl analog of tyramine, which is a well-known biogenic trace amine with which NMT shares many pharmacological properties. Biosynthetically, NMT is produced by the N-methylation of tyramine via the action of the enzyme phenylethanolamine N-methyltransferase in humans and tyramine N-methyltransferase in plants. N-Methyltyramine is the methylated version of L-Tyramine (through the addition of a methyl group at the N terminal), a naturally occurring monoamine compound that acts as a catecholamine releasing agent. N-Methyltyramine can be found in nature from plants such as barley and Citrus aurantium, the latter being commonly used for Synephrine content (N-Methyltyramine is converted to Synephrine by Dopamine β -hydroxylase). Unlike Synephrine, N-Methyltyramine has not been observed to display any lipolytic activity, due to the lack of a beta-hydroxyl or a beta-ketone. Its mechanisms of action imply that it acts as a peripheral sympathomimetic compound. NMT is similar to Synephrine and Hordenine, with the addition of a hydroxyl group at β distinguishing Synephrine from NMT, and substitution of a dimethyl group at the N terminal resulting in Hordenine. In general, when dealing with sympathomimetic compounds, a primary or secondary aliphatic amine separated by 2 carbons from a substituted benzene ring is minimally required for high agonist activity. Along with possessing this characteristic common to adrenergic agents, the presence of a hydroxyl group in the benzene ring at the 4th position shows that N-Methyltyramine has excellent alpha and beta activity adrenergic receptor activity.

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