NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). It forms NADP with the addition of a phosphate group to the 2' position of the adenosyl nucleotide through an ester linkage. 

1. NADH helps enzymes in your body convert food into energy in the form of adenosine triphosphate (ATP). Studies suggest that some people with ME/CFS have low levels of ATP.3

2. NADH can stimulate brain function, which may help alleviate the cognitive dysfunction associated with ME/CFS.1

3. NADH may reduce fatigue by restoring the function of the mitochondria (tiny structures that power your cells). ME/CFS is believed to involve mitochondrial dysfunction.3

4. NADH may help your brain create neurotransmitters, chemical messengers that influence mood and cognitive function (including serotonin, norepinephrine, and dopamine).