• Nootropic Vinpocetine Powder CAS 42971-09-5

    Vinpocetine is a man-made chemical resembling a substance found in the periwinkle plant Vinca minor. People use it as medicine. Vinpocetine production requires considerable laboratory work, stretching the Dietary Supplement Health and Education Act (DSHEA) definition of a dietary supplement. Vinpocetine is sold by prescription in Germany under the brand name Cavinton. It has also been referred to generically as cavinton. Although website advertising claims that "more than a hundred" safety and effectiveness studies have been funded by the Hungarian manufacturer Gedeon Richter, few double-blind controlled clinical studies have been published. Double-blind controlled clinical studies are considered the gold standard for establishing safety and effectiveness. Because some people think vinpocetine might improve blood flow to the brain, it is used for enhancing memory and preventing Alzheimer's disease and other conditions that harm learning, memory, and information processing skills as people age. Vinpocetine is also used for preventing and reducing the chance of disability and death from ischemic stroke. This is the type of stroke that occurs when a blood clot stops blood flow in the brain, causing brain cells (neurons) to die because they are not receiving oxygen. People try vinpocetine for preventing and treating stroke right after it happens because they think vinpocetine might help keep blood from clotting and might also protect neurons against the harmful effects of oxygen deprivation.

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  • Theacrine Improve Mental Focus And Anti-anxiety CAS2309-49-1

    Theacrine is a naturally occurring chemical that is similar to caffeine. It is found in different types of tea and coffee, as well as in the seeds of the Herrania and Theocrama plant species. It is also found in the tea plant Camellia assamica var. kucha, which has been used traditionally to prolong life and cure the common cold. Theacrine seems to affect the brain similar to caffeine. Like caffeine, theacrine stimulates the central nervous system at higher doses and decreases central nervous system activity at lower doses. But unlike caffeine, theacrine does not seem to affect blood pressure. Theacrine might also lessen liver damage caused by stress and reduce pain and swelling.

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  • Nootropics 9-ME-BC CAS 2527-07-5

    9-Me-BC or 9-Methyl-β-carboline is a novel, dopaminergic , cognitive enhancer. It has been shown to improve DA (dopamine, a neurotranmittter vital to mood, focus, vigilance and wakefulness) by inducing growth of hippocampal dopaminergic neurons. The hippocampus, by the way, is the locus of short term memory formation and storage. In addition, 9-Me-BC also has some anti-inflammatory effects. 9-Methyl-9B-Carboline is a dopaminergic enhancer. It operates primarily thorugh up-modulation, differentiation and a protective effect on dendrities and synapses all the while improving dopamine synthesis tasks.

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  • Most Effective Nootropic 7,8-dihydroxyflavone Powder CAS 38183-03-8

    7,8-Dihydroxyflavone (7,8-DHF) is a naturally occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves. It has been found to act as a potent and selective small-molecule agonist of the tropomyosin receptor kinase B (TrkB) (Kd ≈ 320 nM), the main signaling receptor of the neurotrophin brain-derived neurotrophic factor (BDNF). 7,8-DHF is both orally bioavailable and able to penetrate the blood–brain barrier. A prodrug of 7,8-DHF with greatly improved potency and pharmacokinetics, R7, is under development for the treatment of Alzheimer's disease. 7,8-DHF has demonstrated remarkable therapeutic efficacy in animal models of a variety of central nervous system disorders, including depression, Alzheimer's disease, cognitive deficits in schizophrenia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injury, cerebral ischemia, fragile X syndrome, and Rett syndrome. 7,8-DHF also shows efficacy in animal models of age-associated cognitive impairment and enhances memory consolidation and emotional learning in healthy rodents. In addition, 7,8-DHF possesses powerful antioxidant activity independent of its actions on the TrkB receptor, and protects against glutamate-induced excitotoxicity, 6-hydroxydopamine-induced dopaminergic neurotoxicity, and oxidative stress-induced genotoxicity.

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  • High Purity ISRIB(trans-isomer) CAS 1597403-47-8

    Previously, we identified ISRIB as a potent inhibitor of the integrated stress response (ISR) and showed that ISRIB makes cells resistant to the effects of eIF2α phosphorylation and enhances long-term memory in rodents (Sidrauski et al., 2013). Here, we show by genome-wide in vivo ribosome profiling that translation of a restricted subset of mRNAs is induced upon ISR activation. ISRIB substantially reversed the translational effects elicited by phosphorylation of eIF2α and induced no major changes in translation or mRNA levels in unstressed cells. eIF2α phosphorylation-induced stress granule (SG) formation was blocked by ISRIB. Strikingly, ISRIB addition to stressed cells with pre-formed SGs induced their rapid disassembly, liberating mRNAs into the actively translating pool. Restoration of mRNA translation and modulation of SG dynamics may be an effective treatment of neurodegenerative diseases characterized by eIF2α phosphorylation, SG formation, and cognitive loss.

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  • S Nootropics Series Powder CAS 314728-85-3 Sunifiram

    Sunifiram (DM-235) is a synthetic derivative of piracetam, although due to breaking the pyrrolidone backbone Sunifiram is no longer in the racetam class of drugs (yet by being derived from them, Sunifiram is still commonly associated with this class). Sunifiram has mechanisms similar to nefiracetam in the hippocampus, and similar to that drug sunifiram shows anti-amnesiac properties and is potentially a cognitive enhancer. Sunifiram anti-amnesiac activity is several orders of magnitude greater than piracetam on a per weight basis, and preliminary evidence suggest it has a similarly low toxicity profile. Sunifiram is known as an AMPAkine due to exerting most of its actions via the AMPA receptor (one of the three main subsets of glutamate receptors, alongside NDMA and kainate). This enhancement of AMPA function seems to also rely on enhancing signalling via the glycine binding site of NMDA receptors, although one minimal signalling goes through the NMDA receptor then the benefits on AMPA receptors seem dose-dependent.

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  • Pharmaceutical Grade Nootropic Supplement Fasoracetam CAS110958-19-5

    Fasoracetam, also known by its scientific name (5R)-5-(piperidine-1-carbonyl) pyrrolidin-2-one (which probably doesn’t roll of the tongue as well), is a powerful new nootropic that falls within the subclass of nootropics known as racetams. If you are familiar with nootropics, then you likely know that all racetams are derivatives of piracetam, the original nootropic. Many of these derivatives are more powerful and affect cognition in different ways than piracetam. Fasoracetam is a good example of a piracetam derivative that is stronger than piracetam. Fasoracetam (Fasoracetam) is a nootropic agent belonging to the racetam family of drugs.[1][2] Although it is one of the first known and synthesized derivatives of piracetam, its research and efficacy in humans is limited. Fasoracetam is readily available. Fasoracetam upregulates GABA receptors and may also be beneficial for ADHD either alone or in combination with stimulant medication.

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  • CAS 156223-05-1 Nootropic GTS-21 (DMXB-A) Powder

    GTS-21 (also known as DMBX-A), is a novel, small-molecule, orally active and selective alpha-7 nicotinic acetylcholine (nACh) receptor agonist that has demonstrated memory and cognition enhancement activity in human clinical trials. Athenagen licensed the exclusive rights to the compound and a related library of analogs as part of the acquisition of Osprey Pharmaceutical Company in April 2006. GTS-21 has been studied in multiple Phase I studies in healthy volunteers and one Phase I/II study in schizophrenic patients. In all studies, the compound was well tolerated. In a Phase I multi-dose, double-blind, placebo controlled study in healthy adults, GTS-21 also demonstrated cognitive enhancement across all doses, with a statistically significant improvement in attention related and memory related tasks. GTS-21 was O-demethylated to yield compounds that were then subject to glucuronidation. Three of the metabolites in rat urine were isolated and characterized as 4-OH-GTS-21, 4-OH-GTS-21 glucuronide and 2-OH-GTS-21 glucuronide. The major urinary metabolites were 4-OH-GTS-21 glucuronide and 2-OH-GTS-21 glucuronide. In vitro chemical inhibition of cytochrome P450 in human liver microsomes indicated that CYPIA2 and CYP2E1 were the isoforms primarily responsible for the O-demethylation of GTS-21, with some contribution from CYP3A.

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  • Nootropic CAS 51352-87-5 Pharmaceutical Grade PRL-8-53

    PRL-8-53 is a synthetic nootropic supplement, meaning it was created in a lab. Its full name is methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate. Researchers found that oral supplementation of PRL-8-53 was able to improve avoidance learning in rats. One human study has also been done on PRL-8-53. Each participant ingested a placebo and PRL-8-53, at separate times, in a double blind crossover study. Participants then took a memory test, consisting of twelve monosyllabic words in a particular order. The test was conducted three times, immediately after supplementation, one day after supplementation, and four days after supplementation. People that remembered more than eight words after taking a placebo experienced minor benefits, but people over 30 or with poor short term memory benefitted greatly from supplementation. In some cases, their score on the word test doubled.

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