CAS 314728-85-3

  • S Nootropics Series Powder CAS 314728-85-3 Sunifiram

    Sunifiram (DM-235) is a synthetic derivative of piracetam, although due to breaking the pyrrolidone backbone Sunifiram is no longer in the racetam class of drugs (yet by being derived from them, Sunifiram is still commonly associated with this class). Sunifiram has mechanisms similar to nefiracetam in the hippocampus, and similar to that drug sunifiram shows anti-amnesiac properties and is potentially a cognitive enhancer. Sunifiram anti-amnesiac activity is several orders of magnitude greater than piracetam on a per weight basis, and preliminary evidence suggest it has a similarly low toxicity profile. Sunifiram is known as an AMPAkine due to exerting most of its actions via the AMPA receptor (one of the three main subsets of glutamate receptors, alongside NDMA and kainate). This enhancement of AMPA function seems to also rely on enhancing signalling via the glycine binding site of NMDA receptors, although one minimal signalling goes through the NMDA receptor then the benefits on AMPA receptors seem dose-dependent.

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