SANA (MVD1)

SANA (MVD1) is a novel nitroalkene salicylate derivative investigated as a research compound for creatine-dependent thermogenesis, energy expenditure, and metabolic regulation.

Chemically identified as 5-(2-Nitroethenyl)salicylic acid (also known as 2-Hydroxy-5-(2-nitroethenyl)benzoic acid), SANA is structurally distinct from conventional incretin-based metabolic research compounds. Preclinical research has identified a distinctive mechanism involving creatine metabolism and non-shivering thermogenesis, providing a new research approach for studying energy expenditure and adipose tissue metabolism.

Key Research Interest

SANA has attracted attention because its reported thermogenic activity is associated with the creatine-dependent energy expenditure pathway, rather than relying primarily on the classical UCP1 or AMPK pathways. Research suggests that depletion of creatine substantially reduces the thermogenic response to SANA, highlighting the importance of creatine metabolism in its mechanism of action.

The compound is therefore of interest for research involving:

• Creatine-dependent thermogenesis

• UCP1-independent thermogenesis

• Adipose tissue energy expenditure

• Creatine and phosphocreatine metabolism

• Metabolic flexibility and energy balance

• Obesity and metabolic disease research

• Thermogenic pathway screening

• Structure–activity relationship (SAR) studies

Chemical Information

SANA is also known as MVD1, the development code used during its clinical research program.

Research Background

Published research has reported that SANA promotes non-shivering thermogenesis in both brown and white adipose tissue in preclinical models. The observed response was associated with creatine metabolism and was reported to be independent of UCP1 and AMPK activation.

SANA/MVD1 has also progressed into early human clinical research, where safety, tolerability, pharmacokinetics and exploratory metabolic endpoints have been investigated. These findings make SANA an emerging research tool for studying energy expenditure beyond conventional appetite-centered approaches.

Why SANA Is Interesting for Metabolic Research

Unlike many metabolic research compounds that primarily target appetite, incretin signaling, AMPK, or mitochondrial uncoupling, SANA provides an opportunity to investigate an alternative biological route:

Creatine Metabolism → Futile Creatine Cycling → ATP Utilization → Heat Production → Increased Energy Expenditure

This makes SANA particularly relevant for researchers investigating novel thermogenic mechanisms and the relationship between creatine metabolism, adipose tissue biology and whole-body energy balance.

Research Applications

SANA (MVD1) may be used as a research reference compound in:

Metabolic Research
Investigation of cellular energy expenditure, metabolic adaptation and energy balance.

Adipose Tissue Research
Studies of thermogenic responses in brown and white adipocytes.

Creatine Metabolism
Investigation of the creatine/phosphocreatine cycle and creatine-dependent ATP utilization.

Thermogenesis Research
Evaluation of UCP1-independent and non-shivering thermogenic mechanisms.

Drug Discovery & SAR
Development of structural analogs and investigation of nitroalkene salicylate structure–activity relationships.

Product Quality

Because SANA contains a structurally important nitroalkene moiety and stereochemical/geometric characteristics can influence analytical identification, comprehensive analytical characterization is recommended. HPLC/UPLC, LC-MS and NMR can be used as complementary analytical techniques for identity and purity assessment.

For research-grade material, batch-specific analytical documentation such as HPLC purity, LC-MS, NMR and COA can be provided upon request.

Research Use Only

SANA (MVD1) is supplied as a research-use compound for qualified laboratory and scientific research. It is not marketed as a drug, dietary supplement, food ingredient or therapeutic product. It is not intended for human or veterinary consumption.

For Research Use Only (RUO). Not for human consumption.