• Tivasemtiv /CK-2017357 CAS 1005491-05-3
Tivasemtiv /CK-2017357 CAS 1005491-05-3
  • HHDPHARM
  • Wuhan,China

Wuhan hengheda Pharm offer custom synthesis of Tivasemtiv /CK-2017357 CAS 1005491-05-3.

Tivasemtiv /CK-2017357 CAS 1005491-05-3

Product name

TIRASEMTIV(CK-2017357)

 

Other name

1-(1-Ethylpropyl)-6-ethynyl-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one

CAS

1005491-05-3

Purity

Min 98% by HPLC

MF:

C12H14N4O

MW:

230.26576

Structure

Tivasemtiv

Attention

For Research Use only!


Description:

Tirasemtiv is an activator of the fast skeletal muscle troponin complex. IC50 & Target: Troponin In Vitro: Tirasemtiv is a fast skeletal troponin activator that sensitizes the sarcomere to calcium; this mechanism of action amplifies the response of muscle to neuromuscular input producing greater force when nerve input is reduced. Tirasemtiv selectively sensitizes fast skeletal muscle troponin to calcium (Ca2+), and slows the rate of Ca2+ release from the regulatory troponin complex of fast skeletal muscle. In Vivo: A single dose of Tirasemtiv significantly increases submaximal isometric force, forelimb grip strength, grid hang time, and rotarod performance in a female transgenic mouse model (B6SJL-SOD1G93A) of ALS with functional deficits. Additionally, diaphragm force and tidal volume are significantly higher in Tirasemtiv-treated female B6SJL-SOD1G93A mice. At the 25% deficit


FAQ
Do we have the test reports for our products provided by the independent third party?
Every batch of our product was tested by authorized independent third party, Analysis testing center, Shanghai branch, Chinese Academy of Science. We send goods to customers with test report and COA. Our products were also tested by American Analytical Chemistry Laboratories and Chromadex too....more
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