• Tamoxifen Citrate CAS 54965-24-1 Treat Breast Cancer
Tamoxifen Citrate CAS 54965-24-1 Treat Breast Cancer
  • HHDPHARM
  • Wuhan, China
  • IN STOCK
  • 100KG/month

1. Wuhan hengheda Pharm factory supply tamoxifen citrate
2. High quality with stable supply
3. In stock and fast delivery

Tamoxifen Citrate CAS 54965-24-1 Treat Breast Cancer

Product name


Tamoxifen citrate

Other name

ICI 46474

Istubal

Kessar

Noltam

Nolvadex

TMX

Valodex

Zemide

CAS

54965-24-1

Purity

Min 99% by HPLC

MF:

C32H37NO8

MW:

563.64

Structure

Tamoxifen Citrate

Storage

Ar room temperature

Solubility

Soluble in methanol or ethanol

Appearance

Pure white crystalline solid


Description:

Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, and thus may be characterized as a mixed agonist/antagonist. Tamoxifen is the usual endocrine (anti-estrogen) therapy forhormonereceptor-positivebreast cancer in pre-menopausal women, and is also a standard in post-menopausal women although aromatase inhibitors are also frequently used in that setting. china chemical manufacturer api anti breast cancer tamoxifen

Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not activate it. Because of this competitive antagonism, tamoxifen acts like a key broken off in the lock that prevents any other key from being inserted, preventing estrogen from binding to its receptor. Hence breast cancer cell growth is blocked.


Function:

Tamoxifen Citrate (HHDPHARM) is a potent and selective inhibitor of PKC (protein kinase C). It is known that Tamoxifen Citrate functions in PKC εtranslocation. Studies suggest that Tamoxifen Citrate functions as an estrogen receptor antagonist in breast tissue. Once bound to the estrogen receptor Tamoxifen Citrate will not allow any other ligand to bind to the receptor. In contrast, Tamoxifen Citrate is an agonist towards this receptor in tissues of the endometrium. Studies indicate Tamoxifen Citrate inhibits DNA synthesis and transcription by recruiting co-repressors, which stop estrogen from interacting with genes. When combined with PAX2, Tamoxifen Citrate can inhibit the proliferation of ERBB2. It is also a high affinity activator of the GPR30 receptor. Tamoxifen Citrate is an activator of Estrogen Receptor.

 

 


FAQ
Do we have the test reports for our products provided by the independent third party?
Every batch of our product was tested by authorized independent third party, Analysis testing center, Shanghai branch, Chinese Academy of Science. We send goods to customers with test report and COA. Our products were also tested by American Analytical Chemistry Laboratories and Chromadex too....more
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