• NADP/Nicotinamide Adenine Dinucleotide Phosphate CAS 53-59-8
  • NADP/Nicotinamide Adenine Dinucleotide Phosphate CAS 53-59-8
NADP/Nicotinamide Adenine Dinucleotide Phosphate CAS 53-59-8
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Nicotinamide adenine dinucleotide (NAD) and its relative nicotinamide adenine dinucleotide phosphate (NADP) are two of the most important coenzymes in the cell. NADP is simply NAD with a third phosphate group attached as shown at the bottom of the figure.
Enzymes which use NADP(H) as an electron acceptor or as a cofactor. Nicotinamide adenine dinucleotide phosphate, a redox coenzyme that participates in a variety of enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NADP+) and reduced (NADPH). Analogue of NAD, but NADPH is used extensively in biosynthetic, rather than catabolic pathways as well as in photosynthesis.

NADP/Nicotinamide Adenine Dinucleotide Phosphate CAS 53-59-8

Accumulating evidence has suggested that NAD (including NAD+ and NADH) and NADP (including NADP+ and NADPH) could belong to the fundamental common mediators of various biological processes, including energy metabolism, mitochondrial functions, calcium homeostasis, antioxidation/generation of oxidative stress, gene expression, immunological functions, aging, and cell death: First, it is established that NAD mediates energy metabolism and mitochondrial functions; second, NADPH is a key component in cellular antioxidation systems; and NADH-dependent reactive oxygen species (ROS) generation from mitochondria and NADPH oxidase-dependent ROS generation are two critical mechanisms of ROS generation; third, cyclic ADP-ribose and several other molecules that are generated from NAD and NADP could mediate calcium homeostasis; fourth, NAD and NADP modulate multiple key factors in cell death, such as mitochondrial permeability transition, energy state, poly(ADP-ribose) polymerase-1, and apoptosis-inducing factor; and fifth, NAD and NADP profoundly affect aging-influencing factors such as oxidative stress and mitochondrial activities, and NAD-dependent sirtuins also mediate the aging process. Moreover, many recent studies have suggested novel paradigms of NAD and NADP metabolism. Future investigation into the metabolism and biological functions of NAD and NADP may expose fundamental properties of life, and suggest new strategies for treating diseases and slowing the aging process.


NADP+ Definition

NADP+ is a coenzyme that functions as a universal electron carrier, accepting electrons and hydrogen atoms to form NADPH, or nicotinamide adenine dinucleotide phosphate. NADP+ is created in anabolic reactions, or reaction that build large molecules from small molecules. NADPH donates the hydrogen (H) and associated electrons, oxidizing the molecule to create NADP+. This molecule is typically at a lower concentration than its counterpart NADPH, which favors the release of the hydrogen and electron from NADPH.


Function of NADP

NADP+ functions alongside many enzymes to provide energy to the many reactions in a cell. NADP+ is the used form of NADPH, and must be reduced with more electrons and a hydrogen. This is typically done during photosynthesis in plants, or as part of sugar digestion in animals. The release of energy from the bonds of sugar, or the input of energy from the sun, allows the cells of these organisms to bind hydrogen with two electrons to NADP+, creating NADPH which can move this energy, electrons, and hydrogen to a new reaction within the cell.


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Every batch of our product was tested by authorized independent third party, Analysis testing center, Shanghai branch, Chinese Academy of Science. We send goods to customers with test report and COA. Our products were also tested by American Analytical Chemistry Laboratories and Chromadex too....more
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