• NAD+/β-Nicotinamide Adenine Dinucleotide CAS 53-84-9
  • NAD+/β-Nicotinamide Adenine Dinucleotide CAS 53-84-9
NAD+/β-Nicotinamide Adenine Dinucleotide CAS 53-84-9
  • Wuhan Hengheda Pharm Co.,Ltd
  • China
  • Immediately after payment
  • 100kg/month

Nicotinamide Adenine Dinucleotide NAD+ is a water-soluble vitamin, Nicotinamide Adenine Dinucleotide NAD+ is white crystalline powder, odorless or nearly odorless, bitter in taste, freely soluble in water or ethanol, dissolvable in glycerin.

Nicotinamide Adenine Dinucleotide NAD+ is easy to absorb oral, and can be widely distributed in the body, the excess metabolites or prototype quickly expel from urine. Nicotinamide is part of coenzyme I and coenzyme II, plays the role of hydrogen delivery in biological oxidation respiratory chain, can promote biological oxidation processes and tissue metabolism, maintain normal tissue (especially the skin, digestive tract and nervous system) integrity has an important role.

In addition, Nicotinamide Adenine Dinucleotide NAD+ has prevention and treatment of heart block, sinus node function and anti-fast experimental arrhythmias, nicotinamide can significantly improve the heart rate and atrioventricular block caused by verapamil.

NAD+/β-Nicotinamide Adenine Dinucleotide CAS 53-84-9

Nucleosides are glycosylamines that can be thought of as nucleotides without a phosphate group. A nucleoside consists simply of a nucleobase (also termed a nitrogenous base) and a five-carbon sugar (either ribose or deoxyribose), whereas a nucleotide is composed of a nucleobase, a five-carbon sugar, and one or more phosphate groups. In a nucleoside, the anomeric carbon is linked through a glycosidic bond to the N9 of a purine or the N1 of a pyrimidine. Examples of nucleosides include cytidineuridineadenosineguanosinethymidineand inosine.

 

While a nucleoside is a nucleobase linked to a sugar, a nucleotide is composed of a nucleoside and one or more phosphate groups. Thus, nucleosides can be phosphorylated by specific kinases in the cell on the sugar's primary alcohol group (-CH2-OH) to produce nucleotides. Nucleotides are the molecular building-blocks of DNA and RNA.

Nucleosides can be produced by de novo synthesis pathways, in particular in the liver, but they are more abundantly supplied via ingestion and digestion of nucleic acids in the diet, whereby nucleotidases break down nucleotides (such as the thymidine monophosphate) into nucleosides (such as thymidine) and phosphate. The nucleosides, in turn, are subsequently broken down:

  • in the lumen of the digestive system by nucleosidases into nucleobases and ribose or deoxyribose.

In addition, nucleotides can be broken down:

In medicine several nucleoside analogues are used as antiviral or anticancer agents. The viral polymerase incorporates these compounds with non-canonical bases. These compounds are activated in the cells by being converted into nucleotides. They are administered as nucleosides since charged nucleotides cannot easily cross cell membranes.

In molecular biology, several analogues of the sugar backbone exist. Due to the low stability of RNA, which is prone to hydrolysis, several more stable alternative nucleoside/nucleotide analogues that correctly bind to RNA are used. This is achieved by using a different backbone sugar. These analogues include LNAmorpholinoPNA.

In sequencing, dideoxynucleotides are used. These nucleotides possess the non-canonical sugar dideoxyribose, which lacks 3' hydroxyl group (which accepts the phosphate). It therefore cannot bond with the next base and terminates the chain, as DNA polymerases cannot distinguish between it and a regular deoxyribonucleotide.


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Every batch of our product was tested by authorized independent third party, Analysis testing center, Shanghai branch, Chinese Academy of Science. We send goods to customers with test report and COA. Our products were also tested by American Analytical Chemistry Laboratories and Chromadex too....more
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