- Wuhan Hengheda Pharm Co.,Ltd
- China
- Immediately after payment
- 1000kg/month
Pre Workout Supplement N-Methyl Tyramine hydrochloride, N-Methyltyramine HCL
N-Methyltyramine (NMT), also known as 4-hydroxy-N-methylphenethylamine, is a human trace amine and natural phenethylamine alkaloid found in a variety of plants. As the name implies, it is the N-methyl analog of tyramine, which is a well-known biogenic trace amine with which NMT shares many pharmacological properties. Biosynthetically, NMT is produced by the N-methylation of tyramine via the action of the enzyme phenylethanolamine N-methyltransferase in humans and tyramine N-methyltransferase in plants.
N-Methyltyramine is the methylated version of L-Tyramine (through the addition of a methyl group at the N terminal), a naturally occurring monoamine compound that acts as a catecholamine releasing agent. N-Methyltyramine can be found in nature from plants such as barley and Citrus aurantium, the latter being commonly used for Synephrine content (N-Methyltyramine is converted to Synephrine by Dopamine β -hydroxylase). Unlike Synephrine, N-Methyltyramine has not been observed to display any lipolytic activity, due to the lack of a beta-hydroxyl or a beta-ketone. Its mechanisms of action imply that it acts as a peripheral sympathomimetic compound. NMT is similar to Synephrine and Hordenine, with the addition of a hydroxyl group at β distinguishing Synephrine from NMT, and substitution of a dimethyl group at the N terminal resulting in Hordenine.
In general, when dealing with sympathomimetic compounds, a primary or secondary aliphatic amine separated by 2 carbons from a substituted benzene ring is minimally required for high agonist activity. Along with possessing this characteristic common to adrenergic agents, the presence of a hydroxyl group in the benzene ring at the 4th position shows that N-Methyltyramine has excellent alpha and beta activity adrenergic receptor activity.
N-Methyl Tyramine Hydrochloride CAS 370-98-9
Specifications
CAS No.:370-98-9
Other Names:N-Methyl Tyramine HCL
MF:C9H14ClNO
EINECS No.:206-731-3
N-Methyltyramine is the methylated version of L-Tyramine (through the addition of a methyl group at the N terminal), a naturally occurring monoamine compound that acts as a catecholamine releasing agent. N-Methyltyramine can be found in nature from plants such as barley and Citrus aurantium, the latter being commonly used for Synephrine content (N-Methyltyramine is converted to Synephrine by Dopamine β -hydroxylase). Unlike Synephrine, N-Methyltyramine has not been observed to display any lipolytic activity, due to the lack of a beta-hydroxyl or a beta-ketone. Its mechanisms of action imply that it acts as a peripheral sympathomimetic compound. NMT is similar to Synephrine and Hordenine, with the addition of a hydroxyl group at β distinguishing Synephrine from NMT, and substitution of a dimethyl group at the N terminal resulting in Hordenine.
In general, when dealing with sympathomimetic compounds, a primary or secondary aliphatic amine separated by 2 carbons from a substituted benzene ring is minimally required for high agonist activity. Along with possessing this characteristic common to adrenergic agents, the presence of a hydroxyl group in the benzene ring at the 4th position shows that N-Methyltyramine has excellent alpha and beta activity adrenergic receptor activity.
Most notably, supplementing with NMT will likely induce effects relating to that of the catecholamines it releases, i.e. increased energy, elevated heart rate, and increased inotropy. Another notable function of NMT is that it is astrong beta-2 adrenergic receptor agonist, which will increase plasma and myocardial cGMP and cAMP levels. Elevated cAMP levels typically translate to greater fat loss by means of increased basal metabolic rate (BMR) and increased oxidation of fatty acids.
Furthermore, NMT also possesses thethe properties of a mild alpha-2 adrenoceptor antagonist. Alpha-2 blockers significantly increase adrenergic, dopaminergic and serotonergic neurotransmitters as well as increase insulin secretion and decrease blood sugar levels. This makes NMT a great addition to fat burners.
Every batch of our product was tested by authorized independent third party, Analysis testing center, Shanghai branch, Chinese Academy of Science. We send goods to customers with test report and COA. Our products were also tested by American Analytical Chemistry Laboratories and Chromadex too....more
