- HHDPHARM
- Wuhan, China
- IN STOCK
- 100g-1kg/month
1. Wuhan hengheda Pharm offer high quality IACS-10759 CAS:1570496-34-2
2. MIN 98% by HPLC
3. FAST DELIVERY
IACS-10759 (IACS-010759 ) CAS 1570496-34-2
Product name | IACS-10759 (IACS-010759 )
| Other name | 5-(5-methyl-1-(3-(4-(methylsulfonyl)piperidin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole | ||
CAS | 1570496-34-2 | Purity | Min 98% | ||
MF: | C25H25F3N6O4S | MW: | 562.5640096 | ||
Structure |  | ||||
Storage | At room temperature | Solubility | IN DMSO | ||
Attention | For Research Use only! | ||||
Description:
IACS-010759 is an orally bioavailable, potent inhibitor of complex I of oxidative phosphorylation (OXPHOS). IACS-010759 was active in mouse, rat and cynomolgus monkey with IC50 values of 5.6 nM, 12.2 nM and 8.7 nM, respectively. Treatment with IACS-010759 robustly inhibited proliferation and induced apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS, likely owing to a combination of energy depletion and reduced aspartate production that leads to impaired nucleotide biosynthesis.
KEYWORDS: IACS-010759 | supplier | OxPhos inhibitor | IACS-10759 | IACS 010759 | IACS010759 | IACS 10759 | IACS10759 | CAS [1570496-34-2] | NADH | NADH dehydrogenase | Inhibitor | Enzymes | OxPhos | Complex I | Brain cancer | AML
Every batch of our product was tested by authorized independent third party, Analysis testing center, Shanghai branch, Chinese Academy of Science. We send goods to customers with test report and COA. Our products were also tested by American Analytical Chemistry Laboratories and Chromadex too....more
