• IACS-10759 (IACS-010759 ) CAS 1570496-34-2
IACS-10759 (IACS-010759 ) CAS 1570496-34-2
  • HHDPHARM
  • Wuhan, China
  • IN STOCK
  • 100g-1kg/month

1. Wuhan hengheda Pharm offer high quality IACS-10759 CAS:1570496-34-2
2. MIN 98% by HPLC
3. FAST DELIVERY

IACS-10759 (IACS-010759 ) CAS 1570496-34-2

Product name

IACS-10759 (IACS-010759 )

 

Other name

5-(5-methyl-1-(3-(4-(methylsulfonyl)piperidin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

CAS

1570496-34-2

Purity

Min 98%

MF:

C25H25F3N6O4S

MW:

562.5640096

Structure

IACS-10759

Storage

At room temperature

Solubility

IN DMSO

Attention

For Research Use only!



Description:

IACS-010759 is an orally bioavailable, potent inhibitor of complex I of oxidative phosphorylation (OXPHOS). IACS-010759 was active in mouse, rat and cynomolgus monkey with IC50 values of 5.6 nM, 12.2 nM and 8.7 nM, respectively. Treatment with IACS-010759 robustly inhibited proliferation and induced apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS, likely owing to a combination of energy depletion and reduced aspartate production that leads to impaired nucleotide biosynthesis.

KEYWORDS: IACS-010759 | supplier | OxPhos inhibitor | IACS-10759 | IACS 010759 | IACS010759 | IACS 10759 | IACS10759 | CAS [1570496-34-2] | NADH | NADH dehydrogenase | Inhibitor | Enzymes | OxPhos | Complex I | Brain cancer | AML


FAQ
Do we have the test reports for our products provided by the independent third party?
Every batch of our product was tested by authorized independent third party, Analysis testing center, Shanghai branch, Chinese Academy of Science. We send goods to customers with test report and COA. Our products were also tested by American Analytical Chemistry Laboratories and Chromadex too....more
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