• Fexaramine CAS 574013-66-4
Fexaramine CAS 574013-66-4
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  • China
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Fexaramine (CAS 574013-66-4)
Appearance: yellow powders
Purity: 98%
In stock!

Fexaramine (CAS 574013-66-4)

Product name

Fexaramine

Other name

3-[3-[(cyclohexylcarbonyl)[[4'-(dimethylamino)[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoic acid, methyl ester

CAS

574013-66-4

Purity

≥97%

MF:

C32H36N2O3

MW:

496.647

Structure

Fexaramine

Attention

For Research Use only!


Description:  

The farnesoid X receptor (FXR) is a nuclear receptor that acts as a bile acid sensor, protecting cells and organs against bile acid toxicity and coordinating cholesterol metabolism, lipid homeostasis, and absorption of dietary fats and vitamins. Fexaramine is an FXR agonist (EC50 = 25 nM) that demonstrates 100-fold increased affinity to FXR compared to endogenous bile acids and 3-fold increased potency compared to the high affinity FXR agonist GW 4064 (Item No. 10006611; EC50 = 80 nM).1 Fexaramine does not display activity at the following nuclear receptors: hRXRα, hPPARαγδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ, or hVDR.

Fexaramine that leads to weight loss without typical side effects in animal models. Fexaramine tricks the body into reacting as if it has consumed calories and could lead to an effective treatment for type 2 diabetes and obesity in humans.


FAQ
Do we have the test reports for our products provided by the independent third party?
Every batch of our product was tested by authorized independent third party, Analysis testing center, Shanghai branch, Chinese Academy of Science. We send goods to customers with test report and COA. Our products were also tested by American Analytical Chemistry Laboratories and Chromadex too....more
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