- HHDPHARM
- Wuhan, China
- IN STOCK
- 100G-1KG/MONTH
1. Wuhan hengheda Pharm offer high quality BH4
2. Good quality with analysis report
3. Fast delivery
BH4/ Tetrahydrobiopterin CAS 17528-72-2
Product name | Tetrahydrobiopterin | Other name | BH4, THB, sapropterin | ||
CAS | 17528-72-2 | Purity | Min 98% | ||
MF: | C9H15N5O3 | MW: | 241.25 | ||
Structure |  | ||||
Storage | Room temperature | Solubility | oxygen-free water (20 mg/ml) | ||
Attention | For Research Use only! | ||||
Description:
In medicine, used for tetrahydro biopterin deficiency preventer of goiter, for laboratory research
Tetrahydrobiopterin (BH4), also known as sapropterin (INN), plays a key role in a number of physiological processes. It is involved in the formation of neurotransmitters, heart and endothelial dysfunction, the immune response, and pain sensitivity .
BH4 is essential for the action of several enzymes, including ones responsible for neurotransmitter synthesis, host defense, and formation of lipids.
BH4 helps in the biosynthesis of the neurotransmitters serotonin, melatonin, dopamine, norepinephrine, epinephrine, and is important for the production of nitric oxide (NO).
Reduction in vascular BH4 bioavailability is a central mechanism for the development of impaired NO-mediated microvascular (smaller blood vessels) function in a wide variety of conditions, including diabetes, hypertension, hypercholesterolemia, atherosclerosis, and aging
Tetrahydrobiopterin has clinical trials on autism, ADHD, hypertension, endothelial dysfunction, and chronic kidney disease
The aforementioned disorders also are associated with elevated vascular oxidative stress, and BH4 is particularly susceptible to oxidation by peroxynitrite (ONOO−), a reactive oxygen species byproduct of the NO and superoxide anion (O2·−) reaction
Oxidation of BH4results in promoting the transfer of electrons to molecular oxygen resulting in the production of Superoxide rather than Nitric Oxide
One hypothesis is that exogenously administered BH4 is oxidized rapidly to BH2 upon entering circulation, diffuses into the cell as BH2, and then is recycled back to BH4 via the “salvage” pathway enzyme
Every batch of our product was tested by authorized independent third party, Analysis testing center, Shanghai branch, Chinese Academy of Science. We send goods to customers with test report and COA. Our products were also tested by American Analytical Chemistry Laboratories and Chromadex too....more
