• BH4/ Tetrahydrobiopterin CAS 17528-72-2
BH4/ Tetrahydrobiopterin CAS 17528-72-2
  • HHDPHARM
  • Wuhan, China
  • IN STOCK
  • 100G-1KG/MONTH

1. Wuhan hengheda Pharm offer high quality BH4
2. Good quality with analysis report
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BH4/ Tetrahydrobiopterin CAS 17528-72-2

Product name

Tetrahydrobiopterin

Other name

BH4THB, sapropterin

CAS

17528-72-2

Purity

Min 98%

MF:

C9H15N5O3

MW:

241.25

Structure

BH4

Storage

Room temperature

Solubility

oxygen-free water (20 mg/ml)

Attention

For Research Use only!


Description:

In medicine, used for tetrahydro biopterin deficiency preventer of goiter, for laboratory research

 

Tetrahydrobiopterin (BH4), also known as sapropterin (INN), plays a key role in a number of physiological processes. It is involved in the formation of neurotransmitters, heart and endothelial dysfunction, the immune response, and pain sensitivity .

BH4 is essential for the action of several enzymes, including ones responsible for neurotransmitter synthesis, host defense, and formation of lipids.

 

BH4 helps in the biosynthesis of the neurotransmitters serotonin, melatonin, dopamine, norepinephrine, epinephrine, and is important for the production of nitric oxide (NO).

 

Reduction in vascular BH4 bioavailability is a central mechanism for the development of impaired NO-mediated microvascular (smaller blood vessels) function in a wide variety of conditions, including diabetes, hypertension, hypercholesterolemia, atherosclerosis, and aging 

Tetrahydrobiopterin has clinical trials on autism, ADHD, hypertension, endothelial dysfunction, and chronic kidney disease

 

The aforementioned disorders also are associated with elevated vascular oxidative stress, and BH4 is particularly susceptible to oxidation by peroxynitrite (ONOO−), a reactive oxygen species byproduct of the NO and superoxide anion (O2·−) reaction 

Oxidation of BH4results in promoting the transfer of electrons to molecular oxygen resulting in the production of Superoxide rather than Nitric Oxide 

One hypothesis is that exogenously administered BH4 is oxidized rapidly to BH2  upon entering circulation, diffuses into the cell as BH2, and then is recycled back to BH4 via the “salvage” pathway enzyme

 

 


FAQ
Do we have the test reports for our products provided by the independent third party?
Every batch of our product was tested by authorized independent third party, Analysis testing center, Shanghai branch, Chinese Academy of Science. We send goods to customers with test report and COA. Our products were also tested by American Analytical Chemistry Laboratories and Chromadex too....more
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