• Anastrozole CAS 120511-73-1 Breast Cancer Treatment
Anastrozole CAS 120511-73-1 Breast Cancer Treatment
  • HHDPHARM
  • Wuhan, China
  • IN STOCK
  • 100kg/month

1. Wuhan hengheda Pharm wholesale Anastrozole and anastrozole intermediates
2. High purity with analysis report
3. Fast delivery

 Anastrozole CAS 120511-73-1 Breast Cancer Treatment

Product name

Anastrozole

Other name

  • Anastrol

  • ICI-D 1033

  • ZD 1033

 

CAS

120511-73-1

Purity

Min 99% by HPLC

MF:

C17H19N5

MW:

293.36626

Structure

Anastrozole

Storage

At room temperature

Solubility

DMSO: soluble40mg/mL

Attention

Raw material powders

 

Description:

Anastrozole is an aromatase/CYP19A1 inhibitor (IC50 = 15 nM for human placental aromatase/CYP19A1).1 It is selective for aromatase/CYP19A1 over the cytochrome P450 (CYP) isoforms CYP1A2, CYP2A6, CYP2C9, CYP2D6, and CYP3A (IC50s = 27-650 μM). Anastrozole (0.1 mg/kg) blocks ovulation in mature female rats and androstenedione-stimulated uterine development in pubertal female rats.2 It inhibits peripheral aromatase/CYP19A1 and reduces plasma estradiol concentrations in male pigtailed monkeys when administered at doses greater than 0.1 mg/kg. Anastrozole (0.5 mg/kg) reduces tumor incidence and the number of tumors by 40 and 57%, respectively, as well as increases latency to tumor appearance in a rat model of premenopausal mammary tumorigenesis.3 Formulations containing anastrozole have been used in the treatment of breast cancer.

 

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FAQ
Do we have the test reports for our products provided by the independent third party?
Every batch of our product was tested by authorized independent third party, Analysis testing center, Shanghai branch, Chinese Academy of Science. We send goods to customers with test report and COA. Our products were also tested by American Analytical Chemistry Laboratories and Chromadex too....more
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